When the adrenal glands receive the signal, they release adrenaline into the bloodstream. The hypothalamus transmits a signal through autonomic nerves to the adrenal medulla (inner glands of adrenals). It communicates with the rest of the body through the sympathetic nervous system. The hypothalamus is the brain’s command center. If the amygdala perceives danger, it signals another region of the brain called the hypothalamus. The amygdala plays a role in emotional processing. When you perceive a dangerous or stressful situation, that information is sent to a part of the brain called the amygdala. What happens in the body when you experience a rush of adrenaline?Īn adrenaline rush begins in the brain.